4-Acetoxy-3-phenyl-but-2-enoic acid methyl ester → 4-Acetoxy-3-phenyl-butyric Acid Methyl Ester
Reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH:4]=[C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6][O:7][C:8](=[O:10])[CH3:9]>[Pd].C(O)(=O)C>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6][O:7][C:8](=[O:10])[CH3:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 4-acetoxy-3-phenyl-but-2-enoic acid methyl ester, (1.0 g, 4.27 mmol), 10 wt. % palladium on activated carbon (1.0 g), acetic acid (10 mL) is shaken under an atmosphere of hydrogen on a Parr® Shaker. The mixture is filtered through a pad of Celite® and rinsed with methanol. The solution is concentrated in vacuo to yield 0.93 g (92%) of the title compound.
Workup
- filtrationThe mixture is filtered through a pad of Celite®
- washrinsed with methanol
- concentrationThe solution is concentrated in vacuo
Sources & evidence
- ORD record
- ord-2d0268180b8e432b931028249aef5399
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07087626B2
Reaction notes
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