3-(2-Chlorophenyl)propanoic acid → 3-(2-chlorophenyl)-N-{5-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}propanamide

HRID 82087

Reaction equation

HRID 82087 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([CH3:19])[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][C:29](O)=[O:30]>>[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][C:29]([NH:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([CH3:19])[CH:11]=2)=[O:9])[CH:3]=1)=[O:30]

Participants

3

Reactant 2

HCID 956763-(2-Chlorophenyl)propanoic acidHCID 70817432(5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

Product 1

HCID 708177413-(2-chlorophenyl)-N-{5-[(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}propanamide

Procedure

The title compound was prepared according to the method described above for Example 167 starting from (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 110) and 3-(2-chlorophenyl)propanoic acid.

Sources & evidence

ORD record
ord-627568b631734a9bab194e1144364ebf
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Linked notes

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