Cesium carbonate → HCID 70817494, compound

HRID 82122

Reaction equation

HRID 82122 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[NH:22][CH:21]=3)=[O:19])[CH:17]=2)=[O:10])=[CH:4][CH:3]=1.Br[CH:30]([CH3:35])[C:31]([O:33][CH3:34])=[O:32].C(=O)([O-])[O-].[Cs+].[Cs+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:17]=[C:16]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:30]([CH3:35])[C:31]([O:33][CH3:34])=[O:32])[CH:21]=3)=[O:19])[CH:15]=[N:14][CH:13]=2)=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 95576Methyl 2-bromopropionateHCID 708176452-(4-chlorophenyl)-N-[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylcarbonyl)pyridin-3-yl]acetamide

Product 1

HCID 70817494HCID 70817494, compound

Procedure

The title compound was prepared according to the method described for Example 229 using 2-(4-chlorophenyl)-N-[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylcarbonyl)pyridin-3-yl]acetamide (Example 308), methyl 2-bromopropionate and cesium carbonate. Purified using preparative HPLC (method 1) to afford the title compound.

Workup

  1. customThe title compound was prepared
  2. customPurified

Sources & evidence

ORD record
ord-9a4f5f942894436a8a41558eb19d246d
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Linked notes

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