(4,6-Dichloropyrimidin-5-yl)acetaldehyde → 7-(2-{[tert-Butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

HRID 82139

Reaction equation

HRID 82139 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH:9]=O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[Si:12]([O:19][CH2:20][C:21]([CH3:24])([NH2:23])[CH3:22])([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[Si:12]([O:19][CH2:20][C:21]([N:23]1[C:2]2[N:3]=[CH:4][N:5]=[C:6]([Cl:11])[C:7]=2[CH:8]=[CH:9]1)([CH3:24])[CH3:22])([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 13989292(4,6-Dichloropyrimidin-5-yl)acetaldehydeHCID 148067402-tert-Butyldimethylsilyloxy-1,1-dimethylethylamine

Product 1

HCID 866720737-(2-{[tert-Butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Procedure

The title compound was prepared according to the method described for Preparation 1 using (4,6-dichloropyrimidin-5-yl)acetaldehyde and 1-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-2-amine to afford the title compound as a yellow oil in 38% yield, 377 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-562544deefd84908947959ec5daa2a20
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Linked notes

Loading…