1,1-Dichloroethane → 2,6-Bis(trifluoromethyl)-4-[3-(trifluoromethyl)pyrrolidin-3-yl]pyridine

HRID 821434

Reaction equation

HRID 821434 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][C:10]([C:13]([F:14])([F:15])[F:16])([c:17]2[cH:18][c:19]([C:27]([F:28])([F:29])[F:30])[n:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[CH2:11][CH2:12]1.[Cl:31][C:32]([O:33][CH:34]([Cl:35])[CH3:36])=[O:37].[Cl:38][CH:39]([Cl:40])[CH3:41]>>[NH:8]1[CH2:9][C:10]([C:13]([F:14])([F:15])[F:16])([c:17]2[cH:18][c:19]([C:27]([F:28])([F:29])[F:30])[n:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 63651,1-DichloroethaneHCID 5213051-Chloroethyl chloroformateHCID 866749264-[1-Benzyl-3-(trifluoromethyl)pyrrolidin-3-yl]-2,6-bis(trifluoromethyl)pyridine

Product 1

HCID 532621872,6-Bis(trifluoromethyl)-4-[3-(trifluoromethyl)pyrrolidin-3-yl]pyridine

Sources & evidence

ORD record
ord-8024db80d05b48b8bb4d62878b0c21c6
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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