HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N-(5-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chlorophenyl)acetic acid | HCID 15880 | — |
| Reactant | (5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone | HCID 70817536 | — |
| Product | 2-(4-chlorophenyl)-N-(5-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide | HCID 70817591 | — |
Reaction Steps
The title compound was prepared according to the method described for Examples 73-87 using (5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 103) and 4-chlorophenylacetic acid to afford the title compound as a white solid in 66% yield, 223 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846698B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4710b3d775d3481694da288f5e57bf63 |
| Source note | uspto-grants-2014_09 |