Ethyl bromoacetate → Ethyl (5-fluoro-1H-indazol-1-yl)acetate

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.Br[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:6]=[CH:5]2

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 178424865-Fluoro-1H-indazole

Product 1

HCID 70847706Ethyl (5-fluoro-1H-indazol-1-yl)acetate

Procedure

The title compound was prepared according to the method described for Preparation 93 using 5-fluoro-1H-indazole and ethyl bromoacetate to afford the title compound as an off-white solid in 53% yield, 260 mg.

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-7e975f13f96047f8b9ac8b988684e57f
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846698B2

Reaction notes

Loading…