Bromine → HCID 178524767, compound

HRID 82265

Reaction equation

HRID 82265 reaction equation
[Br:1]Br.[OH:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=1>O>[Br:1][C:12]1[C:4]([OH:3])=[N:5][CH:6]=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 24408BromineHCID 178418479HCID 178418479, compound

Product 1

HCID 178524767HCID 178524767, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Bromine (3.6 mL, 70.5 mmol) was added dropwise to a suspension of 6-Hydroxy-nicotinic acid (7 g, 50.32 mmol) in water (70 mL) at 00° C. and the mixture was stirred at room temperature for 4 hours. The precipitated solid was filtered, washed with cold water and dried to get the title compound as off white solid in 82% yield, 9 g.

Workup

  1. filtrationThe precipitated solid was filtered
  2. washwashed with cold water
  3. customdried

Sources & evidence

ORD record
ord-1169c5edf7c74bc9a8a658c183330218
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Linked notes

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