(2-Methoxy-phenyl)-acetyl isothiocyanate → 1-{4-[2-(1-Ethyl-1H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yloxy]-3-fluoro-phenyl}-3-[2-(2-methoxy-phenyl)-acetyl]-thiourea

HRID 822751Notes

Reaction equation

HRID 822751 reaction equation
[CH2:1]([CH3:2])[n:3]1[cH:4][n:5][c:6](-[c:8]2[cH:9][c:10]3[n:11][cH:12][cH:13][c:14]([O:17][c:18]4[c:19]([F:25])[cH:20][c:21]([NH2:24])[cH:22][cH:23]4)[c:15]3[s:16]2)[cH:7]1.[CH2:26]([n:27]1[cH:28][c:29](-[c:30]2[s:31][c:32]3[c:33]([n:34][cH:35][cH:36][c:37]3[O:38][c:39]3[cH:40][cH:41][c:42]([NH:43][C:44]([NH:45][C:46](=[O:47])[CH2:48][c:49]4[cH:50][cH:51][cH:52][cH:53][c:54]4[F:55])=[S:56])[cH:57][c:58]3[F:59])[cH:60]2)[n:61][cH:62]1)[CH3:63].[CH3:64][O:65][c:66]1[c:67]([CH2:72][C:73](=[O:74])[N:75]=[C:76]=[S:77])[cH:68][cH:69][cH:70][cH:71]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][n:5][c:6](-[c:8]2[cH:9][c:10]3[n:11][cH:12][cH:13][c:14]([O:17][c:18]4[c:19]([F:25])[cH:20][c:21]([NH:24][C:76]([NH:75][C:73]([CH2:72][c:67]5[c:66]([O:65][CH3:64])[cH:71][cH:70][cH:69][cH:68]5)=[O:74])=[S:77])[cH:22][cH:23]4)[c:15]3[s:16]2)[cH:7]1

Participants

4

Reactant 3

HCID 21890860(2-Methoxy-phenyl)-acetyl isothiocyanateHCID 594244554-(2-(1-Ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamineHCID 866042001-{4-[2-(1-Ethyl-1H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yloxy]-3-fluoro-phenyl}-3-[2-(2-fluoro-phenyl)-acetyl]-thiourea

Product 1

HCID 866042011-{4-[2-(1-Ethyl-1H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yloxy]-3-fluoro-phenyl}-3-[2-(2-methoxy-phenyl)-acetyl]-thiourea

Sources & evidence

ORD record
ord-b7f6483cdd8247fdb3e07751d22c7a0f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…