3-Cyclopropyl-3-oxopropanenitrile → 3-Cyclopropyl-1'-methyl-1'H-[1,4']bipyrazolyl-5-ylamine

HRID 82317

Reaction equation

HRID 82317 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([N:7](C(OC(C)(C)C)=O)[NH:8]C(OC(C)(C)C)=O)[CH:4]=[N:3]1.[CH:23]1([C:26](=O)[CH2:27][C:28]#[N:29])[CH2:25][CH2:24]1>>[CH:23]1([C:26]2[CH:27]=[C:28]([NH2:29])[N:7]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=3)[N:8]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 98127633-Cyclopropyl-3-oxopropanenitrileHCID 11426954di-tert-butyl 1-(1-methyl-1H-pyrazol-4-yl)hydrazine-1,2-dicarboxylate

Product 1

HCID 708172523-Cyclopropyl-1'-methyl-1'H-[1,4']bipyrazolyl-5-ylamine

Procedure

The title compound was prepared according to the method described for Preparation 296: using di-tert-butyl 1-(1-methyl-1H-pyrazol-4-yl)hydrazine-1,2-dicarboxylate (Preparation 295) and 3-cyclopropyl-3-oxopropanenitrile to afford the title compound in 48% yield, 1.7 g.

Workup

  1. customThe title compound was prepared
  2. customdescribed for Preparation 296

Sources & evidence

ORD record
ord-11eebda06cdc4a778d8bf1ce3bfc14a1
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Linked notes

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