2-Aminothiophenol → 2-bromo-4,5,6,7-tetrahydro-N-(2-mercaptophenyl)-benzo[b]thiophene-3-carboxamide

Reaction equation

[Br:1][c:2]1[c:3]([C:11](=[O:12])[OH:13])[c:4]2[c:5]([s:6]1)[CH2:7][CH2:8][CH2:9][CH2:10]2.[NH2:18][c:19]1[c:20]([SH:25])[cH:21][cH:22][cH:23][cH:24]1.[S:14]([Cl:15])([Cl:16])=[O:17]>>[Br:1][c:2]1[c:3]([C:11](=[O:13])[NH:18][c:19]2[c:20]([SH:25])[cH:21][cH:22][cH:23][cH:24]2)[c:4]2[c:5]([s:6]1)[CH2:7][CH2:8][CH2:9][CH2:10]2

Participants

Reactant 3

HCID 87132-Aminothiophenol

HCID 24386Thionyl Chloride

HCID 184221372-Bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Product 1

HCID 184222902-bromo-4,5,6,7-tetrahydro-N-(2-mercaptophenyl)-benzo[b]thiophene-3-carboxamide

Sources & evidence

ORD record: ord-4f5c67d3e23b450596a46309c4bbf805
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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