5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 4-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-[2,3']bipyridinyl-6'-ylamine

Reaction equation

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([C:25]([F:26])([F:27])[F:28])[cH:11][c:12](-[c:14]3[cH:15][c:16]([CH3:24])[c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[n:13]2)[cH:7]1.[NH2:29][c:30]1[n:31][cH:32][c:33]([B:36]2[O:37][C:38]([CH3:39])([CH3:40])[C:41]([CH3:42])([CH3:43])[O:44]2)[cH:34][cH:35]1>>[c:2]1(-[c:33]2[cH:32][n:31][c:30]([NH2:29])[cH:35][cH:34]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([C:25]([F:26])([F:27])[F:28])[cH:11][c:12](-[c:14]3[cH:15][c:16]([CH3:24])[c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[n:13]2)[cH:7]1

Participants

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HCID 574687672-(2-Chloro-pyridin-4-yl)-4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 866154564-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-[2,3']bipyridinyl-6'-ylamine

Sources & evidence

ORD record: ord-9646f3298a794d61a3b5033aebacd024
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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