2-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N-methyl-acetamide → 2-(7-{5-Fluoro-4-[2-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-2-ylamino}-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N-methyl-acetamide

Reaction equation

[Cl:20][c:21]1[n:22][cH:23][c:24]([F:43])[c:25]([NH:27][c:28]2[c:29]([O:41][CH3:42])[cH:30][c:31]([N:34]3[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]3)[cH:32][cH:33]2)[n:26]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:16][c:17]1[O:18][CH3:19])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH:14][CH3:15])[CH2:9][CH2:10]2>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:16][c:17]1[O:18][CH3:19])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH:14][CH3:15])[CH2:9][CH2:10]2)[c:21]1[n:22][cH:23][c:24]([F:43])[c:25]([NH:27][c:28]2[c:29]([O:41][CH3:42])[cH:30][c:31]([N:34]3[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]3)[cH:32][cH:33]2)[n:26]1