1-Fluoro-4-(isocyanatomethyl)benzene → 1-(4-Fluorobenzyl)-3-{6-[4-(2-trifluoromethylbenzoyl)piperazin-1-YL]-pyridazin-3-YL}urea

HRID 826330

Reaction equation

HRID 826330 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]=[C:8]=[O:9])[cH:10][cH:11]1.[NH2:12][c:13]1[cH:14][cH:15][c:16]([N:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:26])[c:27]3[c:28]([C:33]([F:34])([F:35])[F:36])[cH:29][cH:30][cH:31][cH:32]3)[CH2:23][CH2:24]2)[n:17][n:18]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[NH:12][c:13]2[cH:14][cH:15][c:16]([N:19]3[CH2:20][CH2:21][N:22]([C:25](=[O:26])[c:27]4[c:28]([C:33]([F:34])([F:35])[F:36])[cH:29][cH:30][cH:31][cH:32]4)[CH2:23][CH2:24]3)[n:17][n:18]2)[cH:10][cH:11]1

Participants

3

Reactant 2

HCID 27333761-Fluoro-4-(isocyanatomethyl)benzeneHCID 66849536[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone

Product 1

HCID 117853551-(4-Fluorobenzyl)-3-{6-[4-(2-trifluoromethylbenzoyl)piperazin-1-YL]-pyridazin-3-YL}urea

Sources & evidence

ORD record
ord-941b3498c302455bb8222e2975db4ae3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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