3-Fluorobenzyl chloride → 1'-[{6-Chloro-1-(3-fluorobenzyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 830568

Reaction equation

HRID 830568 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:25])[c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:26][CH2:27]3)[cH:7][nH:8][c:9]2[cH:10]1.[F:28][c:29]1[cH:30][c:31]([CH2:32][Cl:33])[cH:34][cH:35][cH:36]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:25])[c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:26][CH2:27]3)[cH:7][n:8]([CH2:32][c:31]3[cH:30][c:29]([F:28])[cH:36][cH:35][cH:34]3)[c:9]2[cH:10]1

Participants

3

Reactant 2

HCID 99743-Fluorobenzyl chlorideHCID 596575991'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 596575781'-[{6-Chloro-1-(3-fluorobenzyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Sources & evidence

ORD record
ord-f1f74d49c40c4518b69539bbea304639
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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