Methanol → 2-(4-Chloro-phenyl)-4-(2,2-dimethoxy-ethyl)-thiazole-5-carboxylic acid methyl ester

Reaction equation

[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([CH2:17][CH:18]=[O:19])[n:7][c:8](-[c:10]2[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]2)[s:9]1.[CH3:27][OH:28].[CH:20]([O:21][CH3:22])([O:23][CH3:24])[O:25][CH3:26]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([CH2:17][CH:20]([O:23][CH3:24])[O:25][CH3:26])[n:7][c:8](-[c:10]2[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]2)[s:9]1

Participants

Reactant 3

HCID 887Methanol

HCID 9005Trimethyl orthoformate

HCID 866400002-(4-Chloro-phenyl)-4-(2-oxo-ethyl)-thiazole-5-carboxylic acid methyl ester

Product 1

HCID 674611542-(4-Chloro-phenyl)-4-(2,2-dimethoxy-ethyl)-thiazole-5-carboxylic acid methyl ester

Sources & evidence

ORD record: ord-546fffb5560f4f7eb84f6704cec8f336
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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