2,5-Dichlorothiophene-3-sulfonyl chloride → 1-[(2,5-Dichloro-3-thienyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

HRID 8319

Reaction equation

HRID 8319 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[Cl:23][C:24]1[S:25][C:26]([Cl:33])=[CH:27][C:28]=1[S:29](Cl)(=[O:31])=[O:30]>>[ClH:23].[Cl:23][C:24]1[S:25][C:26]([Cl:33])=[CH:27][C:28]=1[S:29]([N:18]1[C:19]2[C:15](=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:22]=[CH:21][CH:20]=2)[CH:16]=[CH:17]1)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 27360942,5-Dichlorothiophene-3-sulfonyl chlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

Product 1

HCID 102260131-[(2,5-Dichloro-3-thienyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

Procedure

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,5-dichloro-3-thienylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.24 (br, 1 H), 7.78 (d, J=5 Hz, 1 H), 7.72 (s, 1 H), 7.57 (d, J=8 Hz, 1 H), 7.29 (t, J=8 Hz, 1 H), 7.01 (d, J=5 Hz, 1 H), 6.86 (d, J=8 Hz, 1 H), 3.31 (m, 8 H). MS (ESI+) for m/z 416 (M+H)+.

Sources & evidence

ORD record
ord-ad9be4801a754d8082881cce7298696a
Source dataset
uspto-grants-2006_08
Patent number
US07087750B2

Linked notes

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