HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methanesulfonylbenzene-1-sulfonyl chloride → Methyl 2-{[4-(1-piperazinyl)-1H-indol-1-yl]sulfonyl}phenyl Sulfone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methanesulfonylbenzene-1-sulfonyl chloride | HCID 2735178 | — |
| Reactant | tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate | HCID 22015386 | — |
| Product | Methyl 2-{[4-(1-piperazinyl)-1H-indol-1-yl]sulfonyl}phenyl Sulfone Hydrochloride | HCID 10139159 | — |
Reaction Steps
The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2-methylsulfonyl-phenylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.22 (br, 1 H), 8.29 (d, J=-8 Hz, 1 H), 7.99 (t, J=8 Hz, 1 H), 7.90–7.80 (m, 2 H), 7.43 (d, J=8 Hz, 1 H), 7.3 0–7.15 (m, 2 H), 7.04 (d, J=3 Hz, 1 H), 6.85 (d, J=8 Hz, 1 H), 3.56 (s, 3 H), 3.29 (m, 8 H); MS (ESI+) for m/z 420 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087750B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-59b619bc204548cba155922be20a2f11 |
| Source note | uspto-grants-2006_08 |