HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane → 4-((1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptyl)-1-(2-methylbenzenesulfonyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane | HCID 11029795 | — |
| Reactant | 4-Bromo-1-(2-methyl-benzenesulfonyl)-1H-indole | HCID 22015334 | — |
| Product | 4-((1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptyl)-1-(2-methylbenzenesulfonyl)-1H-indole | HCID 68996837 | 19% |
Reaction Steps
The compound was prepared from 4-bromo-1-(2-methyl-benzenesulfonyl)-1H-indole and (1S,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptane according to Method 1 to give 25 mg (19%) of a white solid: 1H NMR (CD3OD) δ 7.91–6.44 (m, 9H), 4.67–4.63 (m, 1H), 4.35–4.33 (m, 1H), 4.09–4.07 (m, 1H), 3.99–3.95 (m, 1H), 3.72–3.70 (m, 1H), 3.21–3.17 (m, 1H), 2.95 (s, 3H), 2.33–2.31 (m, 2H); MS (ESI) 382.1 (M+H)+; Purity (HPLC) >95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087750B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-70012c0a48024771b36f75aabd29de67 |
| Source note | uspto-grants-2006_08 |