3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester → 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid

HRID 83465

Reaction equation

HRID 83465 reaction equation
C([O:3][C:4]([C:6]1[C:7]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][N:12]=2)=[N:8][O:9][CH:10]=1)=[O:5])C.C(OC(C1C(C2C=CC=CN=2)=NOC=1)=O)C>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][O:9][N:8]=2)=[N:12][CH:13]=1

Participants

3

Reactant 2

HCID 666436143-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl esterHCID 666437583-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester

Product 1

HCID 671578103-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acidYield 67%

Procedure

As described for example 358b, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.

Sources & evidence

ORD record
ord-d03f8ea8c7154c77a1dc9a227631559f
Source dataset
uspto-grants-2014_09
Patent number
US08846719B2

Linked notes

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