Ethyl benzoylacetate → 7-Methoxy-2-phenyl-quinoline-3-carboxylic acid

HRID 8347

Reaction equation

HRID 8347 reaction equation
C([O:3][C:4](=[O:14])[CH2:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.ClC1C(C=O)=[CH:24][C:23]2[C:18](=[CH:19][C:20]([O:28][CH2:29]C)=[CH:21][CH:22]=2)[N:17]=1>>[CH3:29][O:28][C:20]1[CH:19]=[C:18]2[C:23]([CH:24]=[C:5]([C:4]([OH:3])=[O:14])[C:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[N:17]2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 7170Ethyl benzoylacetateHCID 7674162-Chloro-7-ethoxyquinoline-3-carbaldehyde

Product 1

HCID 220156727-Methoxy-2-phenyl-quinoline-3-carboxylic acid

Procedure

Following the procedure of Example 36 (a)-(b) substituting ethylbenzoylacetate in step 36 (a) gave the above named compound. LCMS m/e [M+H]+=280.2

Workup

  1. customgave the

Sources & evidence

ORD record
ord-d113d1d13d1a417184600b4984e0e239
Source dataset
uspto-grants-2006_08
Patent number
US07087758B2

Linked notes

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