4,6-Dimethyl-2-methylsulfonylpyrimidine → 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4,6-dimethyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

HRID 836186

Reaction equation

HRID 836186 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH:24]3[CH2:25][CH2:26][c:27]4[cH:28][cH:29][cH:30][cH:31][c:32]43)[CH2:9][CH2:10][c:11]3[cH:12][c:13]([O:18][CH3:19])[c:14]([OH:17])[cH:15][c:16]32)[cH:33][cH:34][c:35]1[O:36][CH3:37].[CH3:38][S:39](=[O:40])(=[O:41])[c:42]1[n:43][c:44]([CH3:49])[cH:45][c:46]([CH3:48])[n:47]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH:24]3[CH2:25][CH2:26][c:27]4[cH:28][cH:29][cH:30][cH:31][c:32]43)[CH2:9][CH2:10][c:11]3[cH:12][c:13]([O:18][CH3:19])[c:14]([O:17][c:42]4[n:43][c:44]([CH3:49])[cH:45][c:46]([CH3:48])[n:47]4)[cH:15][c:16]32)[cH:33][cH:34][c:35]1[O:36][CH3:37]

Participants

3

Reactant 2

HCID 27723824,6-Dimethyl-2-methylsulfonylpyrimidineHCID 227427162-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

Product 1

HCID 227427112-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4,6-dimethyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

Sources & evidence

ORD record
ord-7b238fe803ff4a4d9aa4693fd345a269
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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