HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 83774Generated: October 27, 2026
Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride
https://huagongshe.com/reaction/83774
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-(4-acetamidophenoxy)acetate | HCID 309738 | — |
| Product | 2-(4-Aminophenoxy)acetic acid hydrochloride | HCID 66811488 | 77.6% |
Reaction Steps
(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08846845B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-9069b2e2cf384531903fee23e517008c |
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| Source note | uspto-grants-2014_09 |
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