Water → trans-1-[2-(4-Hydroxycyclohexylamino)-pyrimidin-4-yl]-1,2-dihydroindazol-3-one

HRID 837923

Reaction equation

HRID 837923 reaction equation
[CH3:1][Si:2]([I:3])([CH3:4])[CH3:5].[CH3:6][O:7][c:8]1[n:9][n:10](-[c:17]2[n:18][c:19]([NH:23][CH:24]3[CH2:25][CH2:26][CH:27]([OH:30])[CH2:28][CH2:29]3)[n:20][cH:21][cH:22]2)[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12.[CH:32]([Cl:33])([Cl:34])[Cl:35].[OH2:31]>>[O:7]=[c:8]1[nH:9][n:10](-[c:17]2[n:18][c:19]([NH:23][CH:24]3[CH2:25][CH2:26][CH:27]([OH:30])[CH2:28][CH2:29]3)[n:20][cH:21][cH:22]2)[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12

Participants

5

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 85247Trimethylsilyl iodideHCID 24958799trans-4-[4-(3-Methoxyindazol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol

Product 1

HCID 59743385trans-1-[2-(4-Hydroxycyclohexylamino)-pyrimidin-4-yl]-1,2-dihydroindazol-3-one

Sources & evidence

ORD record
ord-24d28e66eb45447d8cd45edd522093e1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

Loading…