Sodium Carbonate → 1-Propanamine, 3-chloro-N-(3-chloropropyl)-N-methyl-
Reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:11])[CH2:7][CH2:8][CH2:9][Cl:10].C(=O)([O-])[O-].[Na+].[Na+]>>[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:11])[CH2:7][CH2:8][CH2:9][Cl:10]Participants
3
Procedure
In accordance with the present invention, N,N-bis(3-chloropropyl)methylamine hydrochloride is reacted with a base, as for example an alkali metal carbonate such as sodium carbonate, thereby forming the free tertiary amine, N,N,-bis(3-chloropropyl) methylamine, and this tertiary amine is reacted with trimethylamine to form a mixture of the diquaternary salt, bis(3-trimethylammoniopropyl) methylamine dichloride, and the desired monoquaternary salt, 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride; this monoquaternary salt is converted to the corresponding 3-[N-(3-chloropropyl) methylamino]-N,N,N-trimethyl-propan-1-aminium chloride hydrochloride by reaction with hydrochloric acid.