HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Sodium Dithionite → n-{3-Amino-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide

HRID 840096
Notes
Print preview

Reaction equation

HRID 840096 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)(=[O:29])=[O:28])[CH:7]=[CH:8][C:9]=1[NH:10][CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[C:14]([C:22]([F:25])([F:24])[F:23])[CH:13]=1)([O-])=O.[O-]S(S([O-])=O)=O.[Na+].[Na+]>CO.O>[NH2:1][C:4]1[CH:5]=[C:6]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)(=[O:28])=[O:29])[CH:7]=[CH:8][C:9]=1[NH:10][CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:19])[F:20])[CH:15]=[C:14]([C:22]([F:23])([F:24])[F:25])[CH:13]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 24489Sodium DithioniteHCID 22621842n-{3-Nitro-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide

Product 1

HCID 22621789n-{3-Amino-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

N-{3-nitro-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide (8.6 g, 16.6 mmol) in 200 mL methanol are refluxed and within 0.5 h combined with a solution of Na2S2O4 (14.2 g, mmol) in 50 mL water. The mixture is refluxed until totally decolorised (this takes about 1 h). After cooling the mixture is diluted with water. About 100 mL of the methanol/water mixture are distilled off, the resulting solution is cooled, the crystals precipitated are filtered off and washed with water. The crystals are dissolved in ethyl acetate, dried and evaporated down until not quite dry. After cooling the crystals precipitated are filtered off and washed with diethylether.

Workup

  1. temperatureThe mixture is refluxed
  2. customthis takes about 1 h
  3. temperatureAfter cooling the mixture
  4. distillationAbout 100 mL of the methanol/water mixture are distilled off
  5. temperaturethe resulting solution is cooled
  6. customthe crystals precipitated
  7. filtrationare filtered off
  8. washwashed with water
  9. dissolutionThe crystals are dissolved in ethyl acetate
  10. customdried
  11. customevaporated down until not
  12. customquite dry
  13. temperatureAfter cooling the crystals
  14. customprecipitated
  15. filtrationare filtered off
  16. washwashed with diethylether

Sources & evidence

ORD record
ord-333675e0e8684ec5bd7421fcf0cac065
Source dataset
uspto-grants-2002_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06365584B1

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes