HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-[(6-Chloro-2-phenylpyrimidin-4-yl)oxy]-4-(benzyloxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Fenclorim | HCID 77338 | — |
| Reactant | 4-(Benzyloxy)-3-hydroxybenzonitrile | HCID 15453451 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[(6-Chloro-2-phenylpyrimidin-4-yl)oxy]-4-(benzyloxy)benzonitrile | HCID 15480703 | 96.7% |
Reaction Steps
To 4,6-dichloro-2-phenylpyrimidine (1.5 g, 6.7 mmol) in acetonitrile (20 mL) was added Cs2CO3 (2.4 g, 7.4 mmol) and 3-hydroxy-4-(benzyloxy)benzonitrile (1.5 g, 6.5 mmol). After stirring for 24 hours, water was added to the reaction mixture and the resulting solid was collected by suction filtration to give 2.6 g of 3-[(6-chloro-2-phenylpyrimidin-4-yl)oxy]-4-(benzyloxy)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372751B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-2cdae23f3b4b4bfea531ede1b89384d7 |
| Source note | uspto-grants-2002_04 |