Sodium Hydroxide → 1,3-Dihydroisobenzofuran

HRID 842331

Reaction equation

HRID 842331 reaction equation
[OH-].[Na+].O[CH2:4][C:5]1[C:6]([CH2:11][OH:12])=[CH:7][CH:8]=[CH:9][CH:10]=1>>[CH2:11]1[O:12][CH2:4][C:5]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 691531,2-Benzenedimethanol

Product 1

HCID 103271,3-DihydroisobenzofuranYield 96%

Procedure

The procedure of Example 15 was performed except that the pH of the reaction mixture was regulated to 12 by use of sodium hydroxide. The reaction mixture was sampled for analysis. Formation of α,α′-dihydroxy-o-xylene was not observed. Instead, phthalan was formed at a yield of 96% based on α,α′-dichloro-o-xylene.

Workup

  1. aliquotThe reaction mixture was sampled for analysis

Sources & evidence

ORD record
ord-691be264de8b49cb99250fc961fc3048
Source dataset
uspto-grants-2002_04
Patent number
US06372921B1

Linked notes

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