3-Methyl-2-thenoic acid → 5-(3-methyl-2-thienoyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole

HRID 843871

Reaction equation

HRID 843871 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][C:19]1[CH:23]=[CH:22][S:21][C:20]=1[C:24](O)=[O:25]>>[CH3:18][C:19]1[CH:23]=[CH:22][S:21][C:20]=1[C:24]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:25]

Participants

3

Reactant 2

HCID 902693-Methyl-2-thenoic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 226114755-(3-methyl-2-thienoyl)amino-3-(1-methylpiperidin-4-yl)-1H-indoleYield 90.5%

Procedure

Beginning with 7.0 mg (0.03 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 12.8 mg (0.09 mMol) 3-methyl-2-thienoic acid, 9.6 mg (90%) of the title compound were recovered.

Sources & evidence

ORD record
ord-fcc1503bad3b4d5ab557ca9fec9ba627
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Linked notes

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