2-(3-Acetyl-phenoxy)-nicotinic acid → 2-(3-Acetyl-phenoxy)-N-(2-fluoro-4-(1-hydroxy-1-methyl-ethyl)-benzyl)-nicotinamide

HRID 844090

Reaction equation

HRID 844090 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[O:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)(=[O:3])[CH3:2].[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([OH:31])([CH3:30])[CH3:29])=[CH:24][C:23]=1[F:32]>>[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[O:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([OH:31])([CH3:29])[CH3:30])=[CH:24][C:23]=1[F:32])=[O:12])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 122026462-(3-Acetyl-phenoxy)-nicotinic acidHCID 224816482-(4-Aminomethyl-3-fluoro-phenyl)-propan-2-ol

Product 1

HCID 226122332-(3-Acetyl-phenoxy)-N-(2-fluoro-4-(1-hydroxy-1-methyl-ethyl)-benzyl)-nicotinamide

Procedure

Prepared from 2-(3-Acetyl-phenoxy)-nicotinic acid and 2-(4-Aminomethyl-3-fluoro-phenyl)-propan-2-ol. mp 68-70° C.

Sources & evidence

ORD record
ord-05a2a46beda5465d9ec15ebf1e1c2314
Source dataset
uspto-grants-2002_04
Patent number
US06380218B1

Linked notes

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