3-Nitrophthalic anhydride → HCID 22612884, compound

HRID 844225

Reaction equation

HRID 844225 reaction equation
[NH2:1][C@H:2]([C:7](=[O:9])[NH2:8])[CH2:3][C:4]([OH:6])=[O:5].[N+:10]([C:13]1[CH:23]=[CH:22][CH:21]=[C:15]2[C:16](O[C:19](=O)[C:14]=12)=[O:17])([O-:12])=[O:11]>C(O)(=O)C>[N+:10]([C:13]1[CH:23]=[CH:22][CH:21]=[C:15]2[C:14]=1[CH2:19][N:1]([CH:2]([C:7](=[O:9])[NH2:8])[CH2:3][C:4]([OH:6])=[O:5])[C:16]2=[O:17])([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 216313-Nitrophthalic anhydrideHCID 7015702Isoasparagine

Product 1

HCID 22612884HCID 22612884, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of isoaspargine (10 mmol) and 3-nitrophthalic anhydride (10 mmol) in 15 ml of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue is purified by chromatography to afford 3-(4-nitro-1-oxoisoindolin-2-yl)-3-carbamoylpropanoic acid.

Workup

  1. temperatureis heated to reflux
  2. customThe cooled reaction mixture
  3. concentrationis concentrated
  4. customthe residue is purified by chromatography

Sources & evidence

ORD record
ord-de46d8cb93354f8bb9fe0b5ca88f3729
Source dataset
uspto-grants-2002_04
Patent number
US06380239B1

Linked notes

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