2-Chloro-6-methylbenzoic acid → HCID 69335964, compound

HRID 844851

Reaction equation

HRID 844851 reaction equation
C[O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:23])[N:15]([CH3:22])[C:16](=[O:21])[N:17]([CH3:20])[C:18]=2[CH3:19])=[CH:9][CH:8]=1)[NH2:5].[Cl:25][C:26]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[C:27]=1[C:28](O)=[O:29]>>[Cl:25][C:26]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[C:27]=1[C:28]([NH:5][C@H:4]([C:3]([OH:2])=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:23])[N:15]([CH3:22])[C:16](=[O:21])[N:17]([CH3:20])[C:18]=2[CH3:19])=[CH:9][CH:8]=1)=[O:29]

Participants

3

Reactant 2

HCID 888702-Chloro-6-methylbenzoic acidHCID 693369754-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester

Product 1

HCID 69335964HCID 69335964, compound

Procedure

N-[(2-chloro-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine was prepared from 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester and 2-chloro-6-methylbenzoic acid using the general procedures described in example 7 and was obtained as a white solid: mp 238-240° C. FAB-HRMS m/e calcd for C24H24ClN3O5 (M+H) 470.1483, found 470.1489.

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-16918820bab04107ae2b3a0a24e90a2f
Source dataset
uspto-grants-2002_04
Patent number
US06380387B1

Linked notes

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