Methane → 7-amino-[5H]-indeno[1,2-c]pyridazin-3[2H]-one hydrochloride

Participants

Reaction Steps

7-Acetamido-[5H]-indeno[1,2-c]pyridazin-3[2H]-one (2.0 g) in 6N hydrochloric acid (20 ml ) was stirred at reflux for 3 hours. Further water (150 ml ) was then added to give a clear, hot solution which was then treated with charcoal and filtered through diatomaceous earth. Concentration of the filtrate gave a buff precipitate of 7-amino-[5H]-indeno[1,2-c]pyridazin-3[2H]-one hydrochloride (1.3 g) which was collected and recrystallised from water (1.1 g, m.p. >300°); ν(Nujol mull) 3200-2000, and 1696 cm-1 ; δ(DMSO-d6) 3.92 (2H,3,5-H2), 6.90 (1H,m,6-H), 7.21 (1H,m,8-H), 7.30 (1H,s,4-H), 7.71 (1H,d,9-H).

Provenance & Evidence