1,2-Dibromoethane → [1-(4-Chlorophenyl)cyclopropyl]methanamine

HRID 845125

Reaction equation

HRID 845125 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.[CH2:11](Br)[CH2:12]Br>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:9][NH2:10])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 78391,2-DibromoethaneHCID 2415824-Chlorobenzyl cyanide

Product 1

HCID 4120166[1-(4-Chlorophenyl)cyclopropyl]methanamineYield 33%

Procedure

(1-(4-Chlorophenyl)cyclopropyl)methylamine is prepared from 4-chlorophenyl acetonitrile and ethylene dibromide in overall 33% yield as described in Example 1.

Sources & evidence

ORD record
ord-1195249b71ff41a5b8323a482ddaf736
Source dataset
uspto-grants-1988_07
Patent number
US04755594

Linked notes

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