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Ammonium Chloride → HCID 14183059, compound

HRID 845583
Notes
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Reaction equation

HRID 845583 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:27])=[C:5]([C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9].[NH4+].[Cl-]>C(O)C.[Zn]>[CH3:1][C:2]1[NH:3][C:4]([CH3:27])=[C:5]([C:21]([O:23][CH:24]([CH3:25])[CH3:26])=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][OH:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 42514483-Methyl 5-(1-methylethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Product 1

HCID 14183059HCID 14183059, compoundYield 98.5%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 702EthanolSolvent

Procedure

To a solution of 81 (0.75 g, 2 mmol) and NH4Cl (0.26 g, 4.85 mmol) in 86% aqueous ethanol (22 mL) was added zinc powder (0.52 g, 7.95 mmol). The resulting mixture was stirred vigorously at room temperature for 50 minutes. The mixture was filtered, and the solvent was washed with water (40 mL) and dried (MgSO4), and the solvent was removed with a rotary evaporator to obtain 0.71 g of 82 as a yellow oil which was condensed with aldehydes without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. washthe solvent was washed with water (40 mL)
  3. dry with materialdried (MgSO4)
  4. customthe solvent was removed with a rotary evaporator

Sources & evidence

ORD record
ord-99e41ca9406f404fb6798b68233405a7
Source dataset
uspto-grants-1988_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04758669

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes