[[o-(Allyloxy)phenoxy]methyl]oxirane → 6-[4-[2-[3-(2-Allyloxy-phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

HRID 846116

Reaction equation

HRID 846116 reaction equation
[CH2:1]([O:4][C:5]1[CH:15]=[CH:14][CH:13]=[CH:12][C:6]=1[O:7][CH2:8][CH:9]1[O:11][CH2:10]1)[CH:2]=[CH2:3].[NH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]([CH3:33])[CH2:28][C:29](=[O:32])[NH:30][N:31]=2)=[CH:22][CH:21]=1>>[CH2:1]([O:4][C:5]1[CH:15]=[CH:14][CH:13]=[CH:12][C:6]=1[O:7][CH2:8][CH:9]([OH:11])[CH2:10][NH:16][CH2:17][CH2:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:27]([CH3:33])[CH2:28][C:29](=[O:32])[NH:30][N:31]=2)=[CH:24][CH:25]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 5743337[[o-(Allyloxy)phenoxy]methyl]oxiraneHCID 151078236-[4-(2-aminoethoxy)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Product 1

HCID 151078276-[4-[2-[3-(2-Allyloxy-phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-(2-allyloxy-phenoxy)-2,3-epoxypropane and 6-[4-(2-aminoethoxy)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-fb1780bc593243999e9db5d7f7f8d150
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Linked notes

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