HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-[4-(Hexyloxy)phenyl]-3-(4-methoxyphenyl)-2-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| Reactant | p-(Hexyloxy)benzaldehyde | HCID 79816 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-[4-(Hexyloxy)phenyl]-3-(4-methoxyphenyl)-2-butanone | HCID 19885147 | 46% |
Reaction Steps
49.2 g of 3-(4-methoxyphenyl)-2-propanone and 61.8 g of 4-hexyloxybenzaldehyde were added to 100 ml of toluene containing 4 ml of piperidine. The resultant mixture was heated at reflux temperature overnight after which the solvent was removed in vacuo to afford the desired subtitled intermediate (46% yield), b.p. 230°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05135955 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-19e7f61cde12489b985d8cc75dfc7d32 |
| Source note | uspto-grants-1992_08 |