Thionyl Chloride → 2-Cyano-3-phenylprop-2-enoyl chloride
Reaction equation
[C:1]([C:3](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4](O)=[O:5])#[N:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[C:1]([C:3](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([Cl:16])=[O:5])#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
100 ml of benzene was added to 17.3 grams of α-cyanocinnamic acid. 12 ml of thionyl chloride was added dropwise slowly thereto at ambient temperature. The temperature was elevated to 70° C. and the heating was continued until foaming ceased. Benzene and thionyl chloride were distilled off and the residue was dried thoroughly under reduced pressure.
Workup
- customat ambient temperature
- customwas elevated to 70° C.
- distillationBenzene and thionyl chloride were distilled off
- customthe residue was dried thoroughly under reduced pressure
Sources & evidence
- ORD record
- ord-f2b1c9ec8d6e43aba5f66b1550d5fea1
- Source dataset
- uspto-grants-1992_08
- Patent number
- US05137638
Reaction notes
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