(1,1'-Biphenyl)-4-carbonitrile, 4'-(hexyloxy)- → 4-(Hexyloxy)-4'-biphenylcarboxylic acid

HRID 846560

Reaction equation

HRID 846560 reaction equation
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]CC.C(OC1C=CC(C2C=CC(C#N)=CC=2)=CC=1)CCCCC>>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([OH:24])=[O:23])=[CH:20][CH:21]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 162465(1,1'-Biphenyl)-4-carbonitrile, 4'-(hexyloxy)-HCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 35638204-(Hexyloxy)-4'-biphenylcarboxylic acid

Procedure

In the synthesis of 4'-octyloxybiphenyl-4-carboxylic acid of Example 12, the same hydrolysis as in Example 12 was repeated except hat 4'-hexyloxy-4-cyanobiphenyl was used instead of 4'-octyloxy-4-cyanobiphenyl to obtain 4'-hexyloxybiphenyl-4-carboxylic acid. This 4'-hexyloxybiphenyl-carboxylic acid was condensed with (+)-4-(2-methylnonanoyl) phenol in the same manner as in the synthesis of 4-(2-metylnonanoyl) phenyl, 4'-octyloxybiphenyl-4-carboxylic acid ester of Example 13 to synthesize 4-(2-methylnonanoyl) phenyl, 4'-hexyloxybiphenyl-4-carboxylic acid ester having the aforementioned physical and chemical properties.

Workup

  1. customthe same hydrolysis as in Example 12

Sources & evidence

ORD record
ord-40bac2e1e4b6436c9ea7570277a44b0d
Source dataset
uspto-grants-1992_08
Patent number
US05137653

Linked notes

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