Diethylaminoethyl chloride → Sulfoximine, N-(2-(diethylamino)ethyl)-S-phenyl-S-3-pyridinyl-

HRID 848070

Reaction equation

HRID 848070 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)(=[NH:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([N:18]([CH2:22][CH3:23])[CH2:19][CH2:20]Cl)[CH3:17]>>[CH2:16]([N:18]([CH2:22][CH3:23])[CH2:19][CH2:20][N:9]=[S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8])[CH3:17]

Participants

3

Reactant 2

HCID 13364Diethylaminoethyl chlorideHCID 20566260S-phenyl-S-(3-pyridyl)-sulphoximide

Product 1

HCID 3054388Sulfoximine, N-(2-(diethylamino)ethyl)-S-phenyl-S-3-pyridinyl-Yield 46%

Procedure

In a manner analogous to that described in Example 1, Stage 3, from S-phenyl-S-(3-pyridyl)-sulphoximide and 2-diethylaminoethyl chloride, there is obtained, in a yield of 46% of theory, N-(2-diethylaminoethyl)-S-phenyl-S-(3-pyridyl)-sulphoximide. The corresponding dibenzoyltartrate, after recrystallisation from isoporopanol, melts at 130° C.

Sources & evidence

ORD record
ord-138292bf2ba0430790baa1511fb8de5c
Source dataset
uspto-grants-1981_10
Patent number
US04294838

Linked notes

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