Disodium → Tazasubrate

HRID 848110

Reaction equation

HRID 848110 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Na][Na].[SH:16][C:17]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH3:21])[C:18]([OH:20])=[O:19]>C(O)CCC>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([S:16][C:17]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([CH3:21])[C:18]([OH:20])=[O:19])[S:3][C:4]=2[CH:10]=1)[CH3:13]

Participants

5

Reactant 3

HCID 141233DisodiumHCID 3500152-Chloro-6-ethoxybenzo[d]thiazoleHCID 15910000alpha-Mercapto-alpha-methylbenzeneacetic acid

Product 1

HCID 174749Tazasubrate

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 21.4 g of 2-chloro-6-ethoxybenzothiazole, 22.6 g of the disodium salt of 2-mercapto-2-phenylpropionic acid and 200 ml of n-butanol is boiled for 4 hours and is evaporated and worked up in the customary manner to give 2-(6-ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid, m.p. 152°-153°.

Workup

  1. customis evaporated

Sources & evidence

ORD record
ord-bd71f7a719a7494a83737c39639230c7
Source dataset
uspto-grants-1981_10
Patent number
US04294839

Linked notes

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