Toluene → 2-((Thiophen-2-ylmethyl)thio)ethan-1-amine
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][SH:7].[OH-].[K+].Cl.Cl[CH2:12][CH2:13][NH2:14].C1(C)C=CC=CC=1>O>[NH2:14][CH2:13][CH2:12][S:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
The crude product from (a) was taken up under nitrogen in a solution of 128 g of potassium hydroxide (2.3 moles) in 150 ml of water. A solution of 88.2 g (0.76 mole) of 2-chloroethyl amine hydrochloride in 100 ml of water was then added dropwise with stirring at 323° K. After 3 hours on a steam bath, the reaction mixture was taken up with 200 ml of toluene, the toluene phase was washed with 200 ml of water, dried with sodium chloride, concentrated and fractionated in vacuo.
Workup
- washthe toluene phase was washed with 200 ml of water
- dry with materialdried with sodium chloride
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-d52a5a3924ae43f896738efe8fd95083
- Source dataset
- uspto-grants-1981_10
- Patent number
- US04297439
Reaction notes
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