Water → 4-Amino-pyrido[2,3-e]pyrimidin-2-one

HRID 849457

Reaction equation

[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][C:11](N)=[O:12].O>C(OCCOCCO)C>[NH2:9][C:8]1[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:11](=[O:12])[N:10]=1

Participants

Conditions

Temperature: 205 °C

Procedure

A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.

Workup

temperatureHeating
filtrationfiltered
customto collect the precipitate
washThe precipitate was washed with water and ethyl acetate
customto dry

Sources & evidence

ORD record: ord-7ee97355e5a946ffa77f9f3ae2b004a8
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06013650

Linked notes

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