Acrylonitrile → (E)-Methyl 5-acetoxy-2-(2-cyanovinyl)benzoate

HRID 84958

Reaction equation

Br[C:2]1C=CC=C[C:3]=1[CH2:8][C:9]([O:11][CH2:12]C)=[O:10].[C:14](#[N:17])[CH:15]=[CH2:16].[C:18]([O:22][C:23](=[O:26])[CH:24]=C)([CH3:21])([CH3:20])C>>[C:23]([O:22][C:18]1[CH:20]=[CH:2][C:3](/[CH:16]=[CH:15]/[C:14]#[N:17])=[C:8]([CH:21]=1)[C:9]([O:11][CH3:12])=[O:10])(=[O:26])[CH3:24]

Participants

Reactant 3

HCID 7855Acrylonitrile

HCID 15458tert-Butyl acrylate

HCID 2780092Ethyl 2-(2-bromophenyl)acetate

Product 1

HCID 66818718(E)-Methyl 5-acetoxy-2-(2-cyanovinyl)benzoate

Procedure

The title compound was prepared according to the procedure outlined in Example 223A substituting Example 227A for ethyl 2-(2-bromophenyl)acetate and acrylonitrile for t-butylacrylate.

Sources & evidence

ORD record: ord-15583bba256545fe9767f0c25e22b40f
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846951B2

Linked notes

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