HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 85141Generated: October 23, 2026
Hydrochloric Acid → 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid
https://huagongshe.com/en/reaction/85141
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester | HCID 67201807 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid | HCID 67202385 | 93% |
Reaction Steps
A mixture containing 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester (75; 670 mg, 1.65 mmol) in 1M NaOH (27 ml) was stirred at 70° C. for 30 min. The reaction mixture was neutralized with 10% aqueous HCl. The resulting precipitate was collected by filtration and dried to afford 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid 76 (600 mg, 93%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08846947B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-f2382b72b62b4358bbb4218ab9da4204 |
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| Source note | uspto-grants-2014_09 |
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