2,3-Diaminobenzoic acid → 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid

Participants

Reaction Steps

2-Methylnicotinaldehyde (149; 2.18 g, 18 mmol) was subjected to the standard conditions used to prepare substituted benzimidazoles by reaction with 2,3-diaminobenzoic acid 1. The desired product, 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid 150, was obtained by purification using chromatography, followed by crystallization from EtOAc (0.43 g, 11%).

Provenance & Evidence