Methanesulfonyl chloride → Methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][CH2:11][CH2:12][OH:13])=[CH:5][CH:4]=1.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([C:9]#[C:10][CH2:11][CH2:12][O:13][S:17]([CH3:16])(=[O:19])=[O:18])=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 608016064-[4-(Trifluoromethyl)phenyl]but-3-YN-1-OL

Product 1

HCID 86602536Methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester

Procedure

In analogy to the procedure described in example 1G], 4-(4-trifluoromethyl-phenyl)-but-3-yn-1-ol and methanesulfonyl chloride gave the title compound as light yellow oil.

Sources & evidence

ORD record: ord-b81397ea6910461fa3575933154c1ed9
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253192B2

Reaction notes

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