5-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one → 6-Bromo-1,1-dimethyl-3-p-tolyl-1H-indene
Reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)=[CH:7][CH2:8][C:9]2(C)[CH3:12])=[CH:4][CH:3]=1.BrC1C=C2C(=CC=1)C(=O)CC2(C)C>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[CH:7][C:9]2([CH3:8])[CH3:12])=[CH:4][CH:3]=1Participants
3
Procedure
Following a procedure similar to that for the preparation of 7-bromo-1,1-dimethyl-4-p-tolyl-1,2-dihydro-naphthalene (Compound 4) while using 5-bromo-3,3-dimethyl-indan-1-one (Compound 12, 1.00 g, 4.2 mmol) as the starting material yielded the title compound (981 mg, 75% yield) as a colorless oil:
Sources & evidence
- ORD record
- ord-cb8cb2c38d0b405993c1e2f03b8a034b