Ethyl acetate hexane → phenyl N-(3-fluoropropyl)carbamate

Reaction equation

Cl.[F:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:13]([O:16]CC)(=[O:15])C>>[F:2][CH2:3][CH2:4][CH2:5][NH:6][C:13](=[O:15])[O:16][C:9]1[CH:8]=[CH:7][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 21226206Ethyl acetate hexane

HCID 219074553-Fluoropropan-1-amine hydrochloride

Product 1

HCID 22936322phenyl N-(3-fluoropropyl)carbamateYield 29.42%

Procedure

3-Fluoropropylamine hydrochloride (0.92 g (wet), 8.10 mmol) was used for reaction in the same manner as Production Example 310-1, and purification was performed by silica gel column chromatography (hexane/ethyl acetate system) to obtain the title compound (0.470 g, 2.3832 mmol, 29.42%) as pink crystals.

Sources & evidence

ORD record: ord-182d200356244947ab20393b8edefee0
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253286B2

Reaction notes

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