Dichloromethane → 2-(2,2-Dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid
Reaction equation
Br[CH2:2][C:3](=O)[C:4]([OH:6])=[O:5].[C:8]([C:12]([O:14][CH2:15][C:16]([NH2:18])=[S:17])=[O:13])([CH3:11])([CH3:10])[CH3:9].ClCCl>C(O)C>[CH3:10][C:8]([CH3:11])([CH3:9])[C:12]([O:14][CH2:15][C:16]1[S:17][CH:2]=[C:3]([C:4]([OH:6])=[O:5])[N:18]=1)=[O:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of bromopyruvic acid (0.37 g, 2.22 mmol) and 2-(tert-butylcarbonyloxy)thioacetamide (0.41 g, 2.22 mmol) in ethanol (20 ml) was added 4 A molecular sieves (2 g). After stirring for 15 h, 20 mL of dichloromethane was added. The mixture was stirred 5 min and filtered to give the product as a yellow solid.
Workup
- stirringThe mixture was stirred 5 min
- filtrationfiltered
Sources & evidence
- ORD record
- ord-48dd6845f4d24862a7e1bae3c8ad8775
- Source dataset
- uspto-grants-2007_08
- Patent number
- US07259157B2
Reaction notes
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